Department of Chemical Engineering and
Institute of Biosciences and Bioengineering
Rice University
Houston, Texas 77251-1892
* To whom all correspondence should be addressed
Theoretical models for contact-inhibited proliferation of anchorage-dependent cells are presented and compared. Deterministic, stochastic and cellular automata models describing proliferation of non-motile cells are discussed first. Since cell locomotion plays an important role in the regulation of angiogenesis and wound healing, a model that considers cell motility is then discussed. This model is also based on the concept of cellular automata and can accurately describe contact-inhibited proliferation of anchorage-dependent, motile cells. Simulation results predicting the growth of isolated colonies of keratinocytes agree very well with experimental data from the literature.
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